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Population pharmacokinetics of indinavir alone and in combination with ritonavir in HIV-1-infected patients

✍ Scribed by Bregt S. Kappelhoff; Alwin D. R. Huitema; Sanjay U. C. Sankatsing; Pieter L. Meenhorst; Eric C. M. Van Gorp; Jan W. Mulder; Jan M. Prins; Jos H. Beijnen

Book ID: 108641386
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 322 KB
Volume: 60
Category: Article
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.2005.02436.x

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## Abstract The HIV‐1 protease L76V mutation has been described recently as conferring high‐level resistance to lopinavir/ritonavir (LPV/r). The aim was to identify the factors and particularly protease mutations associated with the presence of L76V in treatment‐experienced patients infected with H