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Population Pharmacokinetic and Dynamic Analysis of the Topoisomerase I Inhibitor Lurtotecan in Phase II Studies

✍ Scribed by J.H.M. Schellens; B. Heinrich; M. Lehnert; M.E. Gore; S.B. Kaye; P. Dombernowsky; R. Paridaens; A.T. van Oosterom; J. Verweij; W.J. Loos; H. Calvert; N. Pavlidis; H. Cortes-Funes; J. Wanders; M. Roelvink; C. Sessa; K. Selinger; P.S. Wissel; T. Gamucci; A.R. Hanauske


Book ID
110329083
Publisher
Springer US
Year
2002
Tongue
English
Weight
112 KB
Volume
20
Category
Article
ISSN
0167-6997

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Phase I and pharmacokinetic study of a l
✍ Francis J. Giles; Martin S. Tallman; Guillermo Garcia-Manero; Jorge E. Cortes; D πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 130 KB

## Abstract ## BACKGROUND OSI‐211 is a low‐clearance, unilamellar liposomal formulation of a water‐soluble camptothecin analogue, lurtotecan. OSI‐211 has significant activity in severe combined immunodeficient mouse models of human leukemia. ## METHODS This study was conducted to define the dose