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Population pharmacokinetic analysis of pegylated human erythropoietin in rats

โœ Scribed by Koen Jolling; Juan Jose Perez Ruixo; Alex Hemeryck; Vladimir Piotrovskij; Tony Greway


Book ID
102401051
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
285 KB
Volume
93
Category
Article
ISSN
0022-3549

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The primary mechanism of erythropoietin's (EPO) in vivo elimination and the tissue, or tissues, responsible are unknown. Previous studies indicating that EPO pharmacokinetic (PK) behaviour is nonlinear suggest that EPO elimination takes place by a saturable mechanism. A versatile PK system analysis,