✦ LIBER ✦

Poor prognosis associated with thrombocytosis in patients with cervical cancer

✍ Scribed by Enrique Hernandez; Marc Lavine; Charles J. Dunton; Edward Gracely; Janet Parker

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 324 KB
Volume: 69
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19920615)69:12<2975::aid-cncr2820691218>3.0.co;2-a

No coin nor oath required. For personal study only.

✦ Synopsis

The medical records of 113 patients treated with radiation therapy for invasive cervical cancer between 1975 and 1985 were retrospectively reviewed. Patients with thrombocytosis (platelet count > 400,000/~1) were compared with those with normal platelet counts. Thrombocytosis was present at the initiation of therapy in 20 (17.7%) of the 113 patients. The 5-year cumulative survival rate for the 93 patients with normal platelet counts was 65%, whereas it was 25% for the 20 with thrombocytosis ( P < 0.0001, log-rank test). Using Cox's proportional hazards model, thrombocytosis continued to correlate strongly with poor survival even when adjusted for histologic type, patient age, and disease stage ( P < 0.001). Thrombocytosis is an independent indicator of poor prognosis in patients with cervical cancer.

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