𝔖 Bobbio Scriptorium
✦   LIBER   ✦

High levels of stromelysin-3 correlate with poor prognosis in patients with breast carcinoma

✍ Scribed by Marie-Pierre Chenard; Liam O'Siorain; Stephen Shering; Nicolas Rouyer; Yves Lutz; Catherine Wolf; Paul Basset; Jean-Pierre Belloco; Michael Joseph Duffy

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
422 KB
Volume
69
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Stromelysin 3 (ST3) is a matrix metalloprotease (MMP) expressed in fibroblast-like cells of most human invasive carcinomas. In this investigation, ST3 was measured by semiquantitative immunohistochemistry in I I I primary breast cancers. ST3 levels showed no correlation with tumor size, axillary-node status or tumor grade (Scad-Bloom-Richardson system; SBR) but were significantly associated with higher nuclear grade (modified SBR). In addition, ST3 levels were significantly higher in ductal than in lobular cancers. Patients with high scores of ST3 staining had a shorter disease-free interval and shorter overall survival than patients with low scores. ST3 is thus one of the first MMPs to correlate with patient outcome in breast cancer. These findings are consistent with earlier clinical and experimental observations suggesting that ST3 contributes to breast-cancer progression.

πŸ“œ SIMILAR VOLUMES

High levels of TIMP-2 correlate with adv
High levels of TIMP-2 correlate with adverse prognosis in breast cancer
✍ A. Remacle; K. McCarthy; A. NoΓ«l; T. Maguire; E. McDermott; N. O'Higgins; J.M. F πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 French βš– 77 KB πŸ‘ 2 views

TIMP-2 is an endogenous inhibitor of MMPs. Most data from model systems suggest that high levels of this inhibitor prevent metastasis. In human breast cancers, however, we show that high levels of TIMP-2 correlate with both shortened disease-free interval and overall survival. In primary breast canc

Plasma levels of soluble CD105 correlate
Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer
✍ Chenggang Li; Baoqiang Guo; Phillip B. Wilson; Alan Stewart; Ged Byrne; Nigel Bu πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 French βš– 72 KB πŸ‘ 2 views

CD105 (endoglin), a receptor for transforming growth factor (TGF) ␀1 and ␀3 in vascular endothelial cells, is highly up-regulated in blood vessels of tissues where neovascularisation occurs. It modulates endothelial-mesenchymal signalling and is essential for angiogenesis. Indeed, CD105 knockout mic

High levels of tissue inhibitor of metal
High levels of tissue inhibitor of metalloproteinase-1 predict poor outcome in patients with breast cancer
✍ Kevin McCarthy; Teresa Maguire; Gerald McGreal; Enda McDermott; Niall O'Higgins; πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 French βš– 67 KB πŸ‘ 2 views

Studies from model systems suggest that matrix metalloproteinases (MMPs) are causally involved in tumor progression while tissue inhibitors of MMPs (TIMPs) prevent this progression. Here, we show that concentrations of TIMP-1 are significantly higher in breast carcinomas than in fibroadenomas. In pr

Correlation of tumor size and axillary l
Correlation of tumor size and axillary lymph node involvement with prognosis in patients with T1 breast carcinoma
✍ Anthony L. Abner; Laura Collins; Gloria Peiro; Abram Recht; Steven Come; Lawrenc πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 84 KB πŸ‘ 2 views

## BACKGROUND. The prognosis of patients with T1 breast carcinoma remains controversial. Some studies have shown a low risk of lymph node metastasis and distant failure whereas others have not, possibly due to differences in the definition of tumor size. In this study, the authors assessed the rel