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High levels of TIMP-2 correlate with adverse prognosis in breast cancer

✍ Scribed by A. Remacle; K. McCarthy; A. Noël; T. Maguire; E. McDermott; N. O'Higgins; J.M. Foidart; M.J. Duffy*

Publisher
John Wiley and Sons
Year
2000
Tongue
French
Weight
77 KB
Volume
89
Category
Article
ISSN
0020-7136

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✦ Synopsis

TIMP-2 is an endogenous inhibitor of MMPs. Most data from model systems suggest that high levels of this inhibitor prevent metastasis. In human breast cancers, however, we show that high levels of TIMP-2 correlate with both shortened disease-free interval and overall survival. In primary breast cancers, TIMP-2 levels showed no significant relationship with either tumor size or axillary node status but correlated inversely with estrogen receptor levels. TIMP-2 levels also correlated significantly with those for TIMP-1. We conclude that high levels of endogenous TIMP-2, like other protease inhibitors such as PAI-1 and TIMP-1, correlate with progression of human breast cancer.

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