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Pooled Association Tests for Rare Variants in Exon-Resequencing Studies

✍ Scribed by Alkes L. Price; Gregory V. Kryukov; Paul I.W. de Bakker; Shaun M. Purcell; Jeff Staples; Lee-Jen Wei; Shamil R. Sunyaev

Book ID
113422842
Publisher
American Society of Human Genetics
Year
2010
Tongue
English
Weight
232 KB
Volume
86
Category
Article
ISSN
0002-9297

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## Abstract A combination of common and rare variants is thought to contribute to genetic susceptibility to complex diseases. Recently, next‐generation sequencers have greatly lowered sequencing costs, providing an opportunity to identify rare disease variants in large genetic epidemiology studies.