Polyunsaturated fatty acids and T-cell function: Implications for the neonate
β Scribed by Catherine J. Field; M. Thomas Clandinin; John E. Van Aerde
- Book ID
- 107485072
- Publisher
- Springer-Verlag
- Year
- 2001
- Tongue
- English
- Weight
- 96 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0024-4201
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## Serum -cultured rat W256 carcinosarcoma cells of the monocytoid origin undergo rapid apoptosis in response to the lipoxygenase inhibitor NDGA (nordihydroguaiaretic acid). Exogenous arachidonic acid (AA), in a time-and dosedependent fashion, suppressed NDGA-induced W256 cell apoptosis as well as
Polyunsaturated fatty acids (PUFAs) have been suggested, on the basis of animal-model studies, to be related not only to cancer development but also to chemotherapeutic effects. Controversy persists, however, as to which types of PUFAs are beneficial in terms of chemosensitivity. In this study, we u