We have synthesized (Pro-Pro-BAla), as a model for collagen. The synthetic polytripeptide, mol wt 6.500, exhibits a large negative optical rotation with a very strong negative Cotton effect centered a t 216 nm. The optical rotatory dispersion of (Pro-Pro-BAla), followed a single-term Drude equation
POLYPEPTIDE MODELS OF COLLAGEN. SYNTHESIS OF (PRO-PRO-β-ALA)n
✍ Scribed by Rapaka, Rao S. ;Bhatnagar, Rajendra S.
- Book ID
- 115097196
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 304 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0367-8377
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Our studies on the solution conformation of (Gly-Pro-Sar), and (Gly-Sar-Pro), synthesized as polypeptide models for collagen are reported. It is found that, while (Gly-Pro-Sar), exists in ordered triple-helical conformation, (Gly-Sar-Pro), remains as a disordered random coil in water. Addition of ce
On page 713, in Figure 4, the number at the top of the scale of the y-axis should read 0.0 rather than 2.0.
## Abstract The conformation of (Pro‐Gly‐Phe)~__n__~ in trifluoroethanol was investigated using CD, nmr and ir techniques. After making appropriate correction for the contribution of the phenylalanine chromophore to the observed CD spectra of the polytripeptide at several temperatures, it is found