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Polypeptide models of collagen: Properties of (Pro-Pro-βAla)n

✍ Scribed by Rajendra S. Bhatnagar; Rao S. Rapaka

Publisher
Wiley (John Wiley & Sons)
Year
1975
Tongue
English
Weight
335 KB
Volume
14
Category
Article
ISSN
0006-3525

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✦ Synopsis

We have synthesized (Pro-Pro-BAla), as a model for collagen. The synthetic polytripeptide, mol wt 6.500, exhibits a large negative optical rotation with a very strong negative Cotton effect centered a t 216 nm. The optical rotatory dispersion of (Pro-Pro-BAla), followed a single-term Drude equation and the X, was 19.5 nm. The rotation decreased markedly on heating with the midpoint of the broad transition a t 55°C. Preliminary studies also showed loss of structure in guadinine HCI. The circular dichroism spectrum of the polymer exhibited a deep trough a t 190 nm. The marked similarities of solution properties of (Pro-Pro-BAla), to (Pro-Pro-Gly), suggest that p-alanine can replace glycine in generating collagen-like helix in solution.

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