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Polypeptide constitution of receptors for apamin, a neurotoxin which blocks a class of Ca2+-activated K+ channels

✍ Scribed by Patrick Auguste; Michel Hugues; Michel Lazdunski


Book ID
115921686
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
553 KB
Volume
248
Category
Article
ISSN
0014-5793

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Bis-quinolinium cyclophanes: A novel cla
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Based on the structure-activity analysis of two series of blockers of the small conductance Ca 2+activated K + (SKca) channel, a novel class of bis-quinolinium cyclophane blockers has been designed and synthesised. These compounds exhibit submicromolar activity; UCL 1530 ( 4) is a useful agent since