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Sleep cycle disturbances induced by apamin, a selective blocker of Ca2+-activated K+ channels

โœ Scribed by Gabriel Gandolfo; Hugues Schweitz; Michel Lazdunskias; Claude Gottesmann


Book ID
113128740
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
359 KB
Volume
736
Category
Article
ISSN
0006-8993

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Based on the structure-activity analysis of two series of blockers of the small conductance Ca 2+activated K + (SKca) channel, a novel class of bis-quinolinium cyclophane blockers has been designed and synthesised. These compounds exhibit submicromolar activity; UCL 1530 ( 4) is a useful agent since