Polymorphisms of the IL12B and IL23R Genes Are Associated with Psoriasis
β Scribed by Nair, Rajan P; Ruether, Andreas; Stuart, Philip E; Jenisch, Stefan; Tejasvi, Trilokraj; Hiremagalore, Ravi; Schreiber, Stefan; Kabelitz, Dieter; Lim, Henry W; Voorhees, John J
- Book ID
- 110050203
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 154 KB
- Volume
- 128
- Category
- Article
- ISSN
- 0022-202X
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## Objective Recent reports have confirmed association of single-nucleotide polymorphisms (SNPs) mapping to the interleukin-23 receptor (IL-23R) and IL-12Ξ² genes with psoriasis susceptibility. The aim of this study was to determine whether these variants are also associated with susceptibility to p
## Background: Recent genomic surveys have identified IL23R and IL12B as susceptibility loci for inflammatory bowel disease (IBD). Our aim in the present study was to ascertain whether the IL23R and IL12B associations with IBD are also observed in our population, and to analyze possible genetic in