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Polymorphisms of the HNF1A Gene Encoding Hepatocyte Nuclear Factor-1α are Associated with C-Reactive Protein

✍ Scribed by Alexander P. Reiner; Mathew J. Barber; Yongtao Guan; Paul M. Ridker; Leslie A. Lange; Daniel I. Chasman; Jeremy D. Walston; Gregory M. Cooper; Nancy S. Jenny; Mark J. Rieder; J. Peter Durda; Joshua D. Smith; John Novembre; Russell P. Tracy; Jerome I. Rotter; Matthew Stephens; Deborah A. Nickerson; Ronald M. Krauss


Book ID
116195594
Publisher
American Society of Human Genetics
Year
2008
Tongue
English
Weight
392 KB
Volume
82
Category
Article
ISSN
0002-9297

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One form of maturity-onset diabetes of the young, Type 3 (MODY3), results from mutations in the gene coding for hepatocyte nuclear factor-1␣ (HNF-1␣), a transcription factor first described in the liver. MODY3 is characterized by a defective glucosestimulated insulin secretion. Earlier observations