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Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes

✍ Scribed by A.-H. Harding; R. J. F. Loos; J. Luan; S. O’Rahilly; N. J. Wareham; I. Barroso


Publisher
Springer
Year
2006
Tongue
English
Weight
194 KB
Volume
49
Category
Article
ISSN
0012-186X

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Sterol regulatory element binding protein 1 (SREBP-1) transcription factors play a key role in energy homeostasis by regulating genes involved in both carbohydrate and lipid metabolism, and in adipocyte differentiation. The 5' end of the mRNA-encoding SREBP-1 exists in two forms, designated 1a and 1