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Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer

✍ Scribed by Zhengdong Zhang; Luo Wang; Sheng Wei; Zhensheng Liu; Li-E. Wang; Erich M. Sturgis; Qingyi Wei

Book ID
113568188
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
565 KB
Volume
9
Category
Article
ISSN
1568-7864

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## Abstract Rates of adenocarcinoma of the esophagus (EAC) and esophago‐gastric junction (EGJAC) have increased rapidly in recent decades. The primary risk factors, gastro‐esophageal acid reflux and smoking, are potentially genotoxic through the generation of __N__‐nitroso compounds. The DNA repair