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Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism

✍ Scribed by Baghai, T C; Binder, E B; Schule, C; Salyakina, D; Eser, D; Lucae, S; Zwanzger, P; Haberger, C; Zill, P; Ising, M

Book ID: 110060161
Publisher: Nature Publishing Group
Year: 2006
Tongue: English
Weight: 239 KB
Volume: 11
Category: Article
ISSN: 1359-4184
DOI: 10.1038/sj.mp.4001884

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A recent Japanese study on the angiotensin I converting enzyme gene (ACE) insertion/ deletion polymorphism reported that both the D allele (P < 0.02) and the DD genotype (P < 0.002) were significantly more frequent in affective disorder cases than in controls [Arinami et al., 1996: Biol Psychiatry 4