Polymorphisms and resistance mutations in the protease and reverse transcriptase genes of HIV-1 F subtype Romanian strains
β Scribed by Simona Paraschiv; Dan Otelea; Magdalena Dinu; Daniela Maxim; Mihaela Tinischi
- Book ID
- 118449118
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 225 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1201-9712
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## Abstract The K65R mutation in HIVβ1 reverse transcriptase (RT) can be selected by the RT inhibitors tenofovir (TDF), abacavir (ABC), and didanosine (DDI). Recently, in vitro studies have shown that K65R is selected in tissue culture more rapidly with subtype C than subtype B viruses. The prevale
The emergence of genotypic resistance in protease and reverse transcriptase (RT) gene regions was longitudinally evaluated in plasma samples from a group of 12 HIV-1-infected patients treated with different combination of antiretroviral therapies and selected on the basis of their clinical failure.