## Abstract Folate deficiency is implicated in cancer risk that may be modulated by a genetic variation in the methylenetetrahydrofolate reductase (MTHFR) gene in folate metabolism. We hypothesized that genetic variants in __MTHFR__ are associated with risk of squamous cell carcinoma of the head an
Polymorphisms and haplotypes in methylenetetrahydrofolate reductase gene and head and neck squamous cell carcinoma risk
✍ Scribed by Ana Lívia Silva Galbiatti; Mariangela Torreglosa Ruiz; Juliana Olsen Rodrigues; Luiz Sérgio Raposo; José Victor Maníglia; Érika Cristina Pavarino; Eny Maria Goloni-Bertollo
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 324 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0301-4851
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Differences in genetic susceptibility to tobacco-induced carcinogenesis appear to modulate an individual's risk of squamous-cell carcinoma of the head and neck (SCCHN). Risk for SCCHN may be associated with the null alleles of the carcinogen-metabolizing genes glutathione-S-transferase (GST) T1 and
Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS) are known to play a role in DNA methylation, synthesis, and repair. The genetic mutations in MTHFR and TYMS genes may have influences on their respective enzyme activities. Data on the association studies of the MTHFR and TY
## Background: Squamous cell carcinoma (scc) of the head and neck region is rare in young patients and even less frequent in children 15 years or younger children. the patients reported in the literature are isolated cases and their management is always difficult because there is no large experienc