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Polymorphism of pentanucleotide repeats in the 5′ flanking region of glutathione S-transferase (GST) π gene

✍ Scribed by Shoji Harada; Takako Nakamura; Shogo Misawa

Publisher
Springer
Year
1994
Tongue
English
Weight
194 KB
Volume
93
Category
Article
ISSN
0340-6717

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✦ Synopsis

The upstream sequence of the glutathione S-transferase pi gene contains pentanucleotide (ATAAA) repeats. Analysis of the region using polymerase chain reaction indicated that the repeat sequence was polymorphic and segregation of the polymorphic alleles was codominant heredity. Heterozygosity of the new VNTR was 0.818 in healthy Japanese and 0.794 in American whites. Allelic frequencies among healthy controls and alcoholics as well as other diseases were not significantly different.

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