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Polymorphism in the nuclear factor kappa-B binding promoter region of cyclooxygenase-2 is associated with an increased risk of bladder cancer

✍ Scribed by Sokbom Kang; Yong Beom Kim; Moon-Hong Kim; Kyung-Sik Yoon; Jae Weon Kim; Noh Hyun Park; Yong Sang Song; Daehee Kang; Keun-Young Yoo; Soon Beom Kang; Hyo Pyo Lee


Book ID
116333254
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
98 KB
Volume
217
Category
Article
ISSN
0304-3835

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## Abstract The miR‐34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR‐34 function can impair p53‐mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of __pri‐miR‐34b/c__ (423 bp from th