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Polymorphism in gene for microsomal epoxide hydrolase as risk factor in lung cancer

✍ Scribed by Šalagovič, J.; Stubňa, J.; Habalová, V.; Kalina, I.; Biroš, E.

Book ID
118575775
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
84 KB
Volume
25
Category
Article
ISSN
0169-5002

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## Abstract Microsomal epoxide hydrolase (mEPHX) is a critical metabolic enzyme involved in the activation and subsequent detoxification of specific tobacco carcinogens. __mEPHX__ harbors polymorphisms in exon 3 and exon 4 that modulate enzymatic activity. The exon 3 polymorphism decreases mEPHX me