The human T-cell receptor (Tcr) Vb6 family has been scrutinized for polymorphisms, both in coding as well as in intronic sequences by polymerase chain reaction (PCR), subsequent multiple electroblot hybridizations, and sequence analysis. Multiplex PCR is an efficient means of screening for Tcr varia
Polymorphism and phylogeny of dinucleotide repeats in human T-cell receptorVb6genes
β Scribed by Patrick Charmley; Patrick Concannon
- Publisher
- Springer-Verlag
- Year
- 1993
- Tongue
- English
- Weight
- 573 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0093-7711
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The T-cell receptor (Tcr) provides specificity for antigen recognition by its variable domain, primarily consisting of two germline encoded variable (I0 region gene segments. Thus it has been suggested that inherited polymorphisms in the TCRV gene segments could contribute to differential immune res
## Abstract We studied rearrangement of human T cell receptor genes (TCR) of CΞ², CΞ³, VΞ³ and JΞ³ in 34 cases of adult T cell leukemia/lymphoma (ATLL), consisting of 29 cases with monoclonally integrated HTLVβI proviral DNA (ATLLβW) and five without monoclonal integration (ATLLβO), in comparison with