𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Novel members and germline polymorphisms in the human T-cell receptorVb6family

✍ Scribed by Maria Gomolka; Cornelia Epplen; Johannes Buitkamp; Jörg T. Epplen

Publisher
Springer-Verlag
Year
1993
Tongue
English
Weight
843 KB
Volume
37
Category
Article
ISSN
0093-7711

No coin nor oath required. For personal study only.

✦ Synopsis

The human T-cell receptor (Tcr) Vb6 family has been scrutinized for polymorphisms, both in coding as well as in intronic sequences by polymerase chain reaction (PCR), subsequent multiple electroblot hybridizations, and sequence analysis. Multiplex PCR is an efficient means of screening for Tcr variability. Four novel loci could be distinguished and several new alleles are described including two pseudogenes. The Vb6 family is characterized by an intronic stretch of simple repetitive (gt)n sequences. These elements are hypervariable, especially in the Vb6. 7 subfamily, where they are particularly long. The unexpected persistence of simple repetitive sequences in Tcr and major histocompatibility complex (MHC) class II genes over extended periods of the vertebrate evolutionary history can be interpreted in parallel terms in both gene families.

📜 SIMILAR VOLUMES

Vb6T-cell receptor elements in artiodact
Vb6T-cell receptor elements in artiodactyls: conservation and germline polymorphisms
✍ Johannes Buitkamp; Franz-Werner Schwaiger; Jörg Thomas Epplen 📂 Article 📅 1993 🏛 Springer-Verlag 🌐 English ⚖ 809 KB

By use of primers specific for human T-cell receptor (Tcr) Vb6 gene elements, a typing system for Tcr Vb variability in several artiodactyl species has been established. The amplified polymorphic locus is homologous to the human Vb6 gene element. Like the human counterpart, the artiodactyl Vb6 eleme

A novel member of the glycosyltransferas
A novel member of the glycosyltransferase family, β3Gn-T2, highly downregulated in invasive human bladder transitional cell carcinomas
✍ Irina Gromova; Pavel Gromov; Julio E. Celis 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 408 KB

## Abstract Differential display reverse transcription (DDRT)–polymerase chain reaction (PCR) was used to compare the transcriptomes of invasive and noninvasive fresh human bladder transitional cell carcinomas. A differentially expressed novel gene sharing structural similarity with the human β3‐ga

Antibodies against three purified struct
Antibodies against three purified structural proteins of the human type-C retrovirus, HTLV, in Japanese adult T-cell leukemia patients, healthy family members, and unrelated normals
✍ Jörg Schüpbach; V. S. Kalyanaraman; M. G. Sarngadharan; Y. Nakao; Y. Ito; Robert 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 French ⚖ 798 KB

## Abstract The immunological relationship of human T‐cell leukemia/lymphoma virus (HTLV) and the virus found in Japanese adult T‐cell leukemia/lymphoma (ATL) was investigated in detail by testing the specific binding of serum antibodies from Japanese ATL patients and normal Japanese donors to the

Identification of seven novel germline m
Identification of seven novel germline mutations in the human E-cadherin (CDH1) Gene
✍ H. More; B. Humar; W. Weber; R. Ward; A. Christian; C. Lintott; F. Graziano; A-M 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 205 KB 👁 1 views

## Communicated by Albert de la Chapelle Hereditary diffuse gastric cancer (HDGC) is a cancer predisposition syndrome caused by germline mutation of the gene encoding the tumour-suppressor E-cadherin (CDH1). We describe the search for CDH1 mutations in 36 new diffuse gastric cancer families. All 1