Loss of heterozygosity (LOH) from the short arm of chromosome 8 is frequent in a variety of malignancies, suggesting the presence of a tumor suppressor gene in this region. Previous studies suggested that this deletion may correlate with higher clinicopathologic stages in colorectal cancer, but othe
β¦ LIBER β¦
Polymorphism and loss of heterozygosity (LOH) of themethylenetetrahydrofolate (MTHFR) enzyme is associated with the development of colorectal cancer
β Scribed by Ryan, Barbara Mary; Molloy, Anne; McManus, Ross; Daly, Jacqueline S.; Scott, John M.; Kelleher, Dermot; Weir, Donald G.
- Book ID
- 123558253
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 171 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0016-5085
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## Abstract Recent studies have shown that loss of heterozygosity (LOH) on chromosome 10q is a frequent event in a number of tumour types including colorectal cancers. Because previous studies have used markers located mainly distally on chromosome 10, we have examined 114 sporadic colorectal adeno
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