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Polymorphic oxidation of debrisoquine in lung cancer patients

✍ Scribed by Benítez, Julio; Ladero, JoséM.; Jara, Carlos; Carrillo, Juan A.; Cobaleda, Jesús; Llerena, Adrián; Vargas, Emilio; Muñoz, Juan J.

Book ID
122802672
Publisher
Elsevier Science
Year
1991
Weight
554 KB
Volume
27
Category
Article
ISSN
0277-5379

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Ifosfamide plasma clearance in relation
Ifosfamide plasma clearance in relation to polymorphic debrisoquine oxidation
✍ Philip A. Philip; Lionel D. Lewis; Christopher A. James; Howard J. Rogers 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 324 KB

Ifosfamide (IF) pharmacokinetics and the plasma (NBP)-alkylating activity were determined in 33 patients with different tumours after the administration of IF as single-agent chemotherapy. All subjects had been phenotyped for debrisoquine oxidation. There is a lack of correlation between the debriso