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Polymorphic debrisoquine oxidation and acute neuroleptic-induced adverse effects

โœ Scribed by E. Spina; M. Ancione; A. E. Rosa; M. Meduri; A. P. Caputi

Book ID
104692482
Publisher
Springer
Year
1992
Tongue
English
Weight
191 KB
Volume
42
Category
Article
ISSN
0031-6970

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โœ T. D. Leemann; K. P. Devi; P. Dayer ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Springer ๐ŸŒ English โš– 721 KB

The influence of phenotype (debrisoquine type of oxidation polymorphism) and quinidine on (+/-)-metoprolol distribution parameters was investigated in 7 young male volunteers (4 extensive and 3 poor metabolisers). (+/-)-Metoprolol tartrate 20 mg was administered as a 20 min infusion i) alone, ii) 12