Polymers for Tissue Engineering

✍ Scribed by M. Shoichet, J.A. Hubbell

• Publisher: Brill Academic Publishers
• Year: 1998
• Tongue: English
• Leaves: 447
• Edition: 0
• Category: Library

✦ Synopsis

Tissue engineering thrives on collaboration across traditional disciplines, combining polymer science and drug delivery with cell biology, immunology and surgery. A wealth of knowledge has been gained from both the materials science and the cell and molecular biology communities in the development of new or modified bio-materials for implantation. Although there exists a greater foundation today for the development of new implantable materials for tissue engineered devices, there still remains a significant amount to learn.

The articles included in this book highlight the important advances in polymer science that impact tissue engineering. The breadth of polymer science is well represented with the relevance of both polymer chemistry and morphology emphasized in terms of cell and tissue response. This book contains contributions from leaders in the field that are representative of current research endeavors and should serve to stimulate further work to move the approaches of tissue engineering with biomedical polymers closer to widespread clinical impact.

✦ Table of Contents

Contents......Page 6
Foreword......Page 10
New Polymers......Page 14
Mechanical properties of a self-assembling oligopeptide matrix......Page 16
Elastic protein-based polymers in soft tissue augmentation and generation......Page 32
Synthesis and characterization of polymer–(multi)-peptide conjugates for control of specific cell aggregation......Page 66
Synthesis and characterization of degradable polyurethane elastomers containing an amino acid-based chain extender......Page 86
Preparation and characterization of poly(propylene fumarate-co-ethylene glycol) hydrogels......Page 112
Creating biomimetic micro-environments with synthetic polymer–peptide hybrid molecules......Page 126
Polymer Modification......Page 138
Enhancing the interaction of central nervous system neurons with poly(tetrafluoroethylene-co-hexafluoropropylene) via a novel surface amine-functionalization reaction followed by peptide modification......Page 140
Chemical modification and photograft polymerization upon expanded poly(tetrafluoroethylene)......Page 158
Biomolecular modification of p(AAm-co-EG/AA) IPNs supports osteoblast adhesion and phenotypic expression......Page 178
Surface grafting of poly(ethylene glycol) onto poly(acrylamide-co-vinyl amine) cross-linked films under mild conditions......Page 202
Periodontal ligament cell culture on the hydrophobic substrate coated with proteins of periodontal ligament fibroblast-conditioned medium......Page 214
Scaffolds......Page 232
Surface characteristics and biocompatibility of lactide-based poly(ethylene glycol) scaffolds for tissue engineering......Page 234
Poly(vinyl alcohol) synthetic polymer foams as scaffolds for cell encapsulation......Page 248
Skeletal myogenesis on elastomeric substrates: implications for tissue engineering......Page 268
Formation of a spherical multicellular aggregate (spheroid) of animal cells in the pores of polyurethane foam as a cell culture substratum and its application to a hybrid artificial liver......Page 286
Hepatocyte culture utilizing porous polyvinyl formal resin maintains long-term stable albumin secretion activity......Page 300
Role of synthetic extracellular matrix in development of engineered dental pulp......Page 312
Comparative study of the use of poly(glycolic acid), calcium alginate and pluronics in the engineering of autologous porcine cartilage......Page 328
Cultivation of fibroblast cells on keratin-coated substrata......Page 342
Hydrogels......Page 354
Heterogeneous PHPMA hydrogels for tissue repair and axonal regeneration in the injured spinal cord......Page 356
The influence of physical structure and charge on neurite extension in a 3D hydrogel scaffold......Page 388
Complexation of basic fibroblast growth factor with gelatin......Page 410
Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein......Page 426
Subject index......Page 446