Biodegradable Polymer-Based Scaffolds for Bone Tissue Engineering......Page 2
Preface......Page 4
Contents......Page 5
1.1 Tissue Engineering......Page 9
1.2.1 Bone Structure and Composition......Page 10
1.2.2 Mechanical Properties of Bone......Page 11
1.2.3 Existing Approaches for Bone Replacement and Regeneration......Page 12
1.3 Requirements for Scaffolds for Bone Tissue Engineering......Page 13
1.3.2 Physical Properties......Page 14
1.3.5 Sterilizability......Page 15
1.4.1 Biopolymers......Page 16
1.4.1.2 PHB and PHBV Synthesis......Page 18
1.4.1.3 Physical, Mechanical and Miscellaneous Properties of PHB and PHBV......Page 19
1.4.2 Inorganic Materials......Page 20
1.4.3 Biodegradable Polymer Blends......Page 21
1.4.4 Composites......Page 22
References......Page 23
2.1 Scaffold Fabrication Techniques......Page 26
2.1.2 Solvent Casting and Particulate Leaching......Page 27
2.1.3 Polymer Phase Separation......Page 28
2.1.4 Rapid Prototyping......Page 29
2.1.6 Melt Molding......Page 30
2.1.7 Gas Foaming......Page 31
2.1.8 Emulsion FreezingFreeze-Drying Technique......Page 32
2.2 Surface Modification for Bone Tissue Engineering Scaffolds......Page 33
2.3 Protein Adsorption......Page 34
2.4.1 Material and Medium Factors Affecting Degradation......Page 35
2.4.2 General Mechanism of Degradation......Page 36
2.4.3 Kinetics of Degradation......Page 37
2.4.4.1 Polymer Morphology......Page 39
2.4.4.5 Others......Page 40
2.5 Degradation of PLLA and PHB Polymers......Page 41
2.6.1 Factors Affecting Diffusion Phenomena......Page 42
2.6.2 Fickian and Non-Fickian Diffusion in Polymeric Materials......Page 43
2.7.1 Cell Culture......Page 44
References......Page 46
3.1 Fabrication of Biodegradable Polymer Scaffolds Using Emulsion FreezingFreeze-Drying Technique......Page 50
3.2 PolymerCeramic Composite Scaffolds and Characteristics of the Scaffolds......Page 56
3.3 In Vitro Degradation of PHBV and HAPHBV Scaffolds......Page 60
3.4 Surface Modification and In Vitro Biological Evaluation of the Scaffolds......Page 65
References......Page 66
Summary
......Page 68
Index......Page 69