## Abstract A variety of adrenal imaging agents have been used in nuclear medicine, but no agent has been developed for magnetic resonance (MR) imaging. The authors have previously observed accumulation of aminated macromolecules in adrenal glands. They now report the synthesis of a model polymeric
Polymeric gastrointestinal MR contrast agents
β Scribed by Colin Tilcock; Evan C. Unger; Quet Fah Ahkong; Tom Fritz; Seymour H. Koenig; Rodney D. Brown III
- Book ID
- 102374579
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 495 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1053-1807
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β¦ Synopsis
Abstract
Combining either paramagnetic (gadolinium chelatea) or superparamagnetic (ferrite) contrast agents with polymers such as polyethylene glycol or cellulose, or with simple sugars such as dextrose, results in mixtures that exhibit improved T1 and/or T2 relaxivity compared with that of the contrast agent alone. It is suggested that the addition of such inexpensive and nontoxic polymers or saccharides may improve the effectiveness and decrease the cost of enteric contrast agents.
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## Abstract We describe a wellβtolerated blood pool contrast agent with extended reclrculatory halfβlife based on paramagnetic polymerized liposomes (PPLs). PPLs were constructed from a new type of polymerizable lipid molecule that has a derivative of gadopentetate dimeghimine as the hydrophilic he