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Polymerase-Directed Synthesis of 2‘-Deoxy-2‘-fluoro-β- D -arabinonucleic Acids

✍ Scribed by Peng, Chang G.; Damha, Masad J.


Book ID
126193245
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
106 KB
Volume
129
Category
Article
ISSN
0002-7863

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The reaction of [2-14C]-2 ,4-bis-O-(trimethylsilyl)uracil (2) with ~-~-acetyl-~-0-benzoyl-2-deoxy-2-fluoro-~-D-arabinofuranosyl bromide (3) yielded the 3-O-acety1-5-0-benzoyl nucleos e 4 which was hydrolyzed with methanolic ammonia to afford [ 2-feC]-T-( 2-deoxy-2fluoro-p-D-arabinofuranosy1)uracil (