Denaturing high-performance liquid chromatography (DHPLC) compares two or more chromosomes as a mixture of denatured and reannealed PCR amplicons, revealing the presence of a mutation by the differential retention of homo-and heteroduplex DNA on reversed-phase chromatography supports under partial d
Polymerase chain reaction fidelity and denaturing high-performance liquid chromatography
β Scribed by Daniela Muhr; Teresa Wagner; Peter J Oefner
- Book ID
- 108497389
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 318 KB
- Volume
- 782
- Category
- Article
- ISSN
- 1873-376X
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## Communicated by Riccardo Fodde Microsatellite instability (MSI) is a hallmark of the DNA replication error phenotype, due to the inactivation of mismatch repair genes. MSI has been implicated in colon and many other gastrointestinal cancers. MSI usually can be analyzed by PCR amplification of m