Polymer-Supported Catalytic Asymmetric Sharpless Dihydroxylations of Olefins
β Scribed by Carsten Bolm; Arne Gerlach
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 687 KB
- Volume
- 1998
- Category
- Article
- ISSN
- 1434-193X
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β¦ Synopsis
The need for catalyst systems for the asymmetric dihydroxy-polymer or silica gel. After catalysis the ligands can easily be recycled by simple filtration. (b) The alkaloids are anchored lation of olefins (AD) that combine the positive characteristics of the original homogeneous osmium catalysts with the ease to a polymeric unit which allows catalysis to be performed under homogeneous conditions. After the reaction is com-of separation of heterogeneous catalysts led to the introduction of polymer-supported alkaloid ligands. Two major strate-plete, the ligand is isolated by precipitation upon addition of solvent followed by filtration. Recent results of investigations gies for ligand recovery will be discussed here: (a) Attachment of the alkaloids to a solid support, such as an organic of both strategies will be presented.
Carsten Bolm, born in 1960, studied chemistry in Braunschweig (Germany) and at the University of Wisconsin, Madison (USA). He completed his doctorate with Prof. M. T. Reetz in Marburg (Germany) on chiral catalysts for enantioselective CΟͺC coupling. After a postdoctoral stay with Prof.
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followed except acetone'water iis solvent and NMO were used. The reaction mixture contained a small amount of OsO, in t-BuOH (2.5% solution. 13 pL, 0.01 equiv based on olefin), the ligand (0.0025 g, 0.025 equiv), N M O (0.022 g, 1.5 equiv), and tetraethylammonium acetate tetrahydrate (0.033 g, 1 0 e