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Polymer supported calixarene derivative useful for solid-phase synthesis application

โœ Scribed by Giuseppe Granata; Grazia M.L. Consoli; Sebastiano Sciuto; Corrada Geraci

Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
310 KB
Volume
51
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A calix [4]arene derivative has been anchored to carboxyl CPG and TentaGel supports by an easily cleavable ester bond and DMT groups allow a simple loading evaluation via UV-vis spectroscopy. The loading of the calixarene on TentaGel resin has also been estimated by HR-MAS NMR experiments. The potential of the polymer supported calixarenes (9 and 10) in solid phase synthesis has been tested by condensation of four thymine nucleotide units onto the upper rim of the calix[4]arene skeleton.

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