Polymer Based Systems for Tumor-Targeted Gene Delivery
โ Scribed by Wagner, Ernst
- Book ID
- 109827018
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 74 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1087-0156
- DOI
- 10.1038/70131
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Background Efยฎcient and target-speciยฎc in vivo gene delivery is a major challenge in gene therapy. Compared to cell culture application, in vivo gene delivery faces a variety of additional obstacles such as anatomical size constraints, interactions with biological ยฏuids and extracellular matrix, and
## Abstract CPโPEIโFA was prepared as an effective vector for in vitro and in vivo tumorโtargeted gene delivery. The structures of the polymers were characterized, and their DNA condensation capability, particle sizes, zeta potentials, cytotoxicity and in vitro/in vivo transfection were examined. T