Polymer analogs of 3-chloro-4-benzyloxyphenylacetic acid and their pharmacological activity

✍ Scribed by Hrabák, F. ;Grimová, J. ;Maturová, E. ;Kuchař, M.

• Book ID: 102291023
• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 303 KB
• Volume: 17
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.820170114

✦ Synopsis

Polymer analogs of 3-chloro-4-benzyloxyphenylacetic acid (BPh) were prepared, representing esters of BPh with three polymer alcohols: poly(viny1 alcohol) (P-I), poly(2-hydroxyethyl methacrylate) (P-II), and poly(2,3-dihydroxypropyl methacrylate) (P-111). Their anti-inflammatory activity was determined by testing their inhibitory effect on the growth of edema in the hind legs of rats. The relative activities of the esters P-I-BPh and P-11-BPh with respect to that of BPh are 0.06 and 0.10, respectively. In the case of P-111-BPh the activity is stronger (0.37), probably owing to the easier release of BPh from P-111-BPh due to hydrolysis. No prolonged effect of BPh polymeric esters could be achieved.