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Polyfunctional T cell responses are a hallmark of HIV-2 infection

✍ Scribed by Melody G. Duvall; Melissa L. Precopio; David A. Ambrozak; Assan Jaye; Andrew J. McMichael; Hilton C. Whittle; Mario Roederer; Sarah L. Rowland-Jones; Richard A. Koup


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
572 KB
Volume
38
Category
Article
ISSN
0014-2980

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We analyse mathematical models comparing the in vivo dynamics of macrophage-and T cell infection by HIV. Experiments suggest that HIV can only replicate in activated T cells whereas cell activation may not be required for successful replication in macrophages. These assumptions lead to fundamentally