Polyfunctional Cytomegalovirus-Specific CD4+ and pp65 CD8+ T Cells Protect Against High-Level Replication After Liver Transplantation
✍ Scribed by G. Nebbia; F. M. Mattes; C. Smith; E. Hainsworth; J. Kopycinski; A. Burroughs; P. D. Griffiths; P. Klenerman; V. C. Emery
- Book ID
- 114804931
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 308 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1600-6135
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## Abstract We studied the recovery of CMV‐specific CD4^+^ and CD8^+^ T‐cell immunity in 52 recipients of allogeneic stem cell transplantation (SCT). The proportions of IFN‐γ‐producing CD4^+^ and CD8^+^ T cells upon in vitro activation using peptide pools representing the CMV pp65 and IE‐1 proteins
## Abstract The dynamics of CMV pp65 and IE‐1‐specific IFNγ‐producing CD8^+^ (IFNγ CD8^+^) and CD4^+^ (IFNγ CD4^+^) T cells and CMV DNAemia were assessed in 19 pre‐emptively treated episodes of active CMV infection. Peripheral counts of IFNγ CD8^+^ and IFNγ CD4^+^ T cells inversely correlated with