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Lack of prompt expansion of cytomegalovirus pp65 and IE-1-specific IFNγ CD8+ and CD4+ T cells is associated with rising levels of pp65 antigenemia and DNAemia during pre-emptive therapy in allogeneic hematopoietic stem cell transplant recipients

✍ Scribed by Tormo, N; Solano, C; Benet, I; Clari, M A; Nieto, J; de la Cámara, R; López, J; López-Aldeguer, N; Hernández-Boluda, J C; Remigia, M J

Book ID: 109840759
Publisher: Nature Publishing Group
Year: 2009
Tongue: English
Weight: 169 KB
Volume: 45
Category: Article
ISSN: 0007-1188
DOI: 10.1038/bmt.2009.172

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Kinetics of cytomegalovirus (CMV) pp65 a

Kinetics of cytomegalovirus (CMV) pp65 and IE-1-specific IFNγ CD8+ and CD4+ T cells during episodes of viral DNAemia in allogeneic stem cell transplant recipients: Potential implications for the management of active CMV infection

✍ Nuria Tormo; Carlos Solano; Isabel Benet; José Nieto; Rafael de la Cámara; Ana G 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB

## Abstract The dynamics of CMV pp65 and IE‐1‐specific IFNγ‐producing CD8^+^ (IFNγ CD8^+^) and CD4^+^ (IFNγ CD4^+^) T cells and CMV DNAemia were assessed in 19 pre‐emptively treated episodes of active CMV infection. Peripheral counts of IFNγ CD8^+^ and IFNγ CD4^+^ T cells inversely correlated with