Polyether-segmented nylon hemodialysis membranes. I. Preparation and permeability characteristics of polyether-segmented nylon 610 hemodialysis membrane

✍ Scribed by Yukio Seita; Akira Mochizuki; Mitsuhide Nak Agawa; Atsuhiro Takanashi; Shuzo Yamashita

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 168 KB
• Volume: 65
• Category: Article
• ISSN: 0021-8995
• DOI: 10.1002/(sici)1097-4628(19970829)65:9<1703::aid-app6>3.0.co;2-j

✦ Synopsis

The effect of the coagulation condition in the phase inversion method on the permeability characteristics of poly( propylene oxide ) or poly(tetramethylene oxide )segmented nylon 610 (PPO-Ny610 or PTMO-Ny610 ) hemodialysis membranes, the stability of the membrane performance, and the mechanical strength were investigated. The polymers were dissolved in a solvent such as formic acid and methanol saturated with calcium chloride, and thus PPO-Ny610 and PTMO-Ny610 membranes were prepared using formic acid and a calcium chloride /methanol/water mixture as a polymer solvent and a coagulant, respectively. It is concluded that PPO-Ny610 membrane has better permeability characteristics than PTMO-Ny610 membrane, and possesses additional properties for hemodialysis membranes such as mechanical properties and permeability stability in the drying and sterilizing processes. Furthermore, the blood compatibilities of PPO-Ny610 and PTMO-Ny610 membranes were superior to regenerated cellulose membranes on the basis of the result of platelet adhesion test.