Polyether-segmented nylon hemodialysis membrane. V. Evaluation of blood compatibility of polyether-segmented nylons

✍ Scribed by Akira Mochizuki; Yukio Seita; Toshio Nakashima; Fumiaki Endo; Shuzo Yamashita

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 110 KB
• Volume: 67
• Category: Article
• ISSN: 0021-8995
• DOI: 10.1002/(sici)1097-4628(19980214)67:7<1253::aid-app14>3.0.co;2-2

✦ Synopsis

The biocompatibility of poly(propylene oxide)-segmented nylon610 (PPO-Ny610), poly(ethylene oxide)-segmented nylon610 (PEO-Ny610), poly(ethylene oxide)-segmented nylonM10 (PEO-NyM10), and poly(ethylene oxide)-segmented ny-lon69/M10 (PEO-Ny69/M10) hollow fibers were investigated in terms of the transient leukopenia by the extracorporeal circulation in a rabbit. PPO-Ny610 and PEO-Ny610 hollow fibers showed that the minimum leukocyte counts during the circulations were ú 80% against the initial count of leukocyte. These results indicate that these polymers have good blood compatibility. In PEO-NyM10 and PEO-Ny69/M10, the remarkable decreases of the leukocyte count were observed and the minimum counts were in the range of 45-50%. From the evaluation results of homo nylons (Ny610 and NyM10) hollow fibers, the low blood compatibilities observed in PEO-NyM10 and PEO-Ny69/ M10 are not attributed to the chemical structure of the nylon blocks.