Polyclonal B-cell activation is related to exocrine manifestations of primary Sjögren's syndrome
✍ Scribed by Oxholm, Peter; Manthorpe, Rolf; Prause, Jan U.
- Book ID
- 122880755
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 344 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0896-8411
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We sought evidence of Epstein-Barr virus (EBV) involvement in the mechanism of polyclonal B cell activation in 29 patients with Sjogren's syndrome (SS). Serum levels of anti-viral capsid antigen antibodies of both the IgG and the IgM class were significantly elevated in these patients. Excretion of
## Abstract ## Objective To delineate disturbances in peripheral B cell memory in primary Sjögren's syndrome (SS). ## Methods Isotype‐specific immunoglobulin (Ig) heavy‐chain transcripts were analyzed in single‐sorted CD19+,CD27− naive and CD19+,CD27+ memory B cells from patients with primary SS