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Possible involvement of epstein-barr virus in polyclonal b cell activation in sjögren's syndrome

✍ Scribed by Kunio Yamaoka; Nobuyuki Miyasaka; Kohtaro Yamamoto

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
776 KB
Volume
31
Category
Article
ISSN
0004-3591

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✦ Synopsis

We sought evidence of Epstein-Barr virus (EBV) involvement in the mechanism of polyclonal B cell activation in 29 patients with Sjogren's syndrome (SS). Serum levels of anti-viral capsid antigen antibodies of both the IgG and the IgM class were significantly elevated in these patients. Excretion of EBV from the oropharynx was frequently observed, as well. Spontaneously transformed B cell lines that produced a large amount of transforming EBV were established preferentially from SS patients. We also found that an EBVspecific regulatory mechanism was impaired in these patients. Our findings thus provide evidence of the involvement of EBV in patients with SS.

Sjogren's syndrome (SS), an autoimmune exocrinopathy , is associated with disordered immunoregulation that is characterized by defective T cell function ( I ) and augmented B cell activity (2). B cells are polyclonally activated, and various kinds of autoantibodies are detectable in serum. Furthermore, SS car-From the

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