✦ LIBER ✦

Polyaxonal myelination in developing dystrophic and normal mouse nerves

✍ Scribed by Dr. Mark J. Brown; Sandra J. Radich

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 721 KB
Volume: 2
Category: Article
ISSN: 0148-639X
DOI: 10.1002/mus.880020310

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Myelin‐forming Schwann cells in the peripheral nervous system characteristically surround and myelinate only single axons. Polyaxonal myelination is an anomaly of this one‐to‐one relationship whereby one normal‐appearing Schwann cell myelinates multiple axons. We examined the ventral roots and the proximal sciatic and posterior tibial nerves of developing normal mice and of dy^2J^/dy^2J^ dystrophic mice with proximal failure of myelination. Polyaxonal myelination was a rare feature in normal nerves. Examples of polyaxonal myelination were observed six times more often in dystrophic than in normal mice and were most abundant in proximal sciatic nerves. Polyaxonal myelination could result from either an axonal or a Schwann‐cell abnormality, or it may be the nonspecific response of uncommitted Schwann cells to an early failure of myelination.

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