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Polyanions inhibit binding of autoantibodies with some cell proteins

✍ Scribed by Yu. B. Gryaznova; A. E. Kabakov; L. N. Brovkina; V. A. Saenko; E. L. Nasonov; A. M. Poverennyi

Book ID: 104967373
Publisher: Springer US
Year: 1990
Tongue: English
Weight: 585 KB
Volume: 110
Category: Article
ISSN: 0007-4888
DOI: 10.1007/bf00839935

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The influence of charged polymers on the reaction of immunoglobulins from human lupus sera with cellular proteins was investigated in this study. Through immunoblotting it was shown that polyanions (dextran sulfate, heparin, polyinosinic acid) and polylysine inhibited autoantibody binding to several