Polyamines and growth regulation of cultured human breast cancer cells by 17β-oestradiol
✍ Scribed by Hoggard, Nigel; Green, Chris D.
- Book ID
- 122441815
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 641 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0303-7207
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## Abstract Previous studies have demonstrated that cultured human breast fibroblasts secrete a high‐molecular‐weight polypeptide which stimulates the ability of human breast‐cancer MCF‐7 cells to convert oestrone (E1) to the biologically more active 17β‐oestradiol (E2). This effect is mediated by
I7f3-hydroxysteroid dehydrogenase (I 7HSD) type I converts the weakly active estrogen, estrone, into highly active estradiol. In addition to being essential for gonadal estradiol biosynthesis, the enzyme is also expressed in a significant proportion of breast tumors. In order to study the role of th