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Polyamide recognition-mass spectrometry for distinguishing hairpin DNA from coil DNA

โœ Scribed by Bo Zheng; Yiquan Liu; Gu Yuan

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
436 KB
Volume
24
Category
Article
ISSN
0952-3499

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โœฆ Synopsis

The discrimination between hairpin DNA and coil DNA has been well achieved through polyamides as probes by electrospray ionization (ESI) mass spectrometry. ESI mass spectra showed that polyamides bind to hairpin DNA with high selectivity, and almost no binding with coil DNA. In addition, the noncovalent interaction between polyamides and hairpin DNA was also studied; the results show that hairpin DNA with longer stem and polyamides with more heterocycles have higher binding affinity and stability in gas phase. Copyright ยฉ 2011 John Wiley & Sons, Ltd.

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## Abstract A new method for the determination of the relative affinity of a ligand against various dsDNA sequences is presented by using electrospray ionization timeโ€ofโ€flight mass spectrometry (ESIโ€QTOF) mass spectrometry. The principle is described here through the complexation of doubleโ€strande