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Poly-l-lysine Dissolves Fibrillar Aggregation of the Alzheimer β-Amyloid Peptide in Vitro

✍ Scribed by Khue Vu Nguyen; Jean-Louis Gendrault; Charles-Michel Wolff

Book ID
115589563
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
251 KB
Volume
291
Category
Article
ISSN
0006-291X

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Alzheimers disease (AD) is the most frequent cause of late-life dementia, with pathological characteristics of extracellular aggregation of amyloid b-peptides (Abs) with 39 ± 43 amino acids, which are proteolytically derived from the transmembrane amyloid precursor protein (APP). [1] Recent studies