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Polo-like kinase: a novel marker of proliferation: Correlation with estrogen-receptor expression in human breast cancer

✍ Scribed by Georg Wolf; Ralf Hildenbrand; Christian Schwar; Rainer Grobholz; Manfred Kaufmann; Hans-Jochen Stutte; Klaus Strebhardt; Uwe Bleyl


Book ID
117499479
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
1018 KB
Volume
196
Category
Article
ISSN
0344-0338

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The insulin-like growth factors (IGFs) have been implicated in the growth regulation of human breast cancer. Since the lCFs are associated with specific binding proteins (ICFBPs) which may modulate receptor/ligand interactions, production of IGFBPs by breast cancer cells could alter their IGF-depend