𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Polo-box domain: a versatile mediator of polo-like kinase function

✍ Scribed by Jung-Eun Park; Nak-Kyun Soung; Yoshikazu Johmura; Young H. Kang; Chenzhong Liao; Kyung H. Lee; Chi Hoon Park; Marc C. Nicklaus; Kyung S. Lee

Book ID
105759163
Publisher
Springer
Year
2010
Tongue
English
Weight
723 KB
Volume
67
Category
Article
ISSN
1420-682X

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

A Pan-Specific Inhibitor of the Polo-Box
A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis
✍ Wolfgang Reindl; Juping Yuan; Andrea Krämer; Klaus Strebhardt ; Thorsten Berg 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 386 KB

## Abstract **Playing polo**: Small‐molecule inhibitors of polo‐like kinase 1 are mostly ATP‐competitive, and thus face enormous specificity hurdles. This communication explores the concept of inhibiting Plk1 with a small‐molecule inhibitor of the protein–protein interactions required for Plk1 func

Cover Picture: A Pan-Specific Inhibitor
Cover Picture: A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis (ChemBioChem 7/2009)
✍ Wolfgang Reindl; Juping Yuan; Andrea Krämer; Klaus Strebhardt ; Thorsten Berg 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 664 KB

## Abstract **The cover picture shows** the small molecule Poloxipan, a pan‐specific inhibitor of polo‐like kinases (Plks), and its effects on human cancer cells. Most inhibitors of protein kinases such as Plk1, which is a key player in mitosis, inhibit the enzyme ATP‐binding pocket. Due to the con